View source for Logopenic variant primary progressive aphasia

'''Diagnosis''' (Gorno-Tempini et al, 2011)

1) Must have both:

:a. Impaired single-word retrieval in spontaneous speech and naming

:b. Impaired repetition of sentences and phrases

2) And must have at least three of the following:

:a. Speech (phonologic) errors in spontaneous speech and naming

:b. Spared single-word comprehension and object knowledge

:c. Spared motor speech

:d. Absence of frank agrammatism

3) Imaging-supported logopenic variant diagnosis requires clinical diagnosis above plus imaging with at least one of:

:a. Predominant left posterior perisylvian or parietal atrophy on MRI

:b. Predominant left posterior perisylvian or parietal hypoperfusion or hypometabolism on SPECT or PET

4) Logopenic variant PPA with definite pathology diagnosis requires clinical diagnosis above plus either of the following:

:a. Histopathologic evidence of a specific neurodegenerative pathology (e.g., AD, FTLD-tau, FTLD-TDP, other)

:b. Presence of a known pathogenic mutation


'''Pathology'''
- pathology is typically Alzheimer’s disease


== References ==

Gorno-Tempini, M. L. et al. Classification of primary progressive aphasia and its variants. Neurology 76, 1006–1014 (2011). https://pubmed.ncbi.nlm.nih.gov/21325651/