Logopenic variant primary progressive aphasia

Diagnosis (Gorno-Tempini et al, 2011)

1) Must have both:

a. Impaired single-word retrieval in spontaneous speech and naming

b. Impaired repetition of sentences and phrases

2) And must have at least three of the following:

a. Speech (phonologic) errors in spontaneous speech and naming

b. Spared single-word comprehension and object knowledge

c. Spared motor speech

d. Absence of frank agrammatism

3) Imaging-supported logopenic variant diagnosis requires clinical diagnosis above plus imaging with at least one of:

a. Predominant left posterior perisylvian or parietal atrophy on MRI

b. Predominant left posterior perisylvian or parietal hypoperfusion or hypometabolism on SPECT or PET

4) Logopenic variant PPA with definite pathology diagnosis requires clinical diagnosis above plus either of the following:

a. Histopathologic evidence of a specific neurodegenerative pathology (e.g., AD, FTLD-tau, FTLD-TDP, other)

b. Presence of a known pathogenic mutation

Pathology - pathology is typically Alzheimer’s disease

References

Gorno-Tempini, M. L. et al. Classification of primary progressive aphasia and its variants. Neurology 76, 1006–1014 (2011). PubMed link