Difference between revisions of "Amygdala"

(Created page with "An important distinction is amygdala is a subcortical structure involved in mobilization of defense behavior in response to immediate threats and is not the source of consciou...")
 
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An important distinction is amygdala is a subcortical structure involved in mobilization of defense behavior in response to immediate threats and is not the source of conscious experience of anxiety or fear (LeDoux 2017).
 
An important distinction is amygdala is a subcortical structure involved in mobilization of defense behavior in response to immediate threats and is not the source of conscious experience of anxiety or fear (LeDoux 2017).
  
o Lateral amygdala processes incoming sensory stimuli, has capacity to learn (via conditioning) to associate certain stimuli with threat (Johansen et al, 2011).
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Lateral amygdala processes incoming sensory stimuli, has capacity to learn (via conditioning) to associate certain stimuli with threat (Johansen et al, 2011).
  
o Central amygdala processes information from lateral amygdala and may lead to freezing pathways or to basal amygdala and more goal oriented avoidance behaviors (LeDoux and Pine, 2016)
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Central amygdala processes information from lateral amygdala and may lead to freezing pathways or to basal amygdala and more goal oriented avoidance behaviors (LeDoux and Pine, 2016)
  
o More chronic / distant / uncertain threats are processed by the bed nucleus of the stria terminalis (Daniel and Rainnie, 2016; LeDoux and Pine 2016; Yassa et al, 2012)
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More chronic / distant / uncertain threats are processed by the bed nucleus of the stria terminalis (Daniel and Rainnie, 2016; LeDoux and Pine 2016; Yassa et al, 2012)
  
  

Revision as of 16:24, 1 June 2021

An important distinction is amygdala is a subcortical structure involved in mobilization of defense behavior in response to immediate threats and is not the source of conscious experience of anxiety or fear (LeDoux 2017).

• Lateral amygdala processes incoming sensory stimuli, has capacity to learn (via conditioning) to associate certain stimuli with threat (Johansen et al, 2011).

• Central amygdala processes information from lateral amygdala and may lead to freezing pathways or to basal amygdala and more goal oriented avoidance behaviors (LeDoux and Pine, 2016)

• More chronic / distant / uncertain threats are processed by the bed nucleus of the stria terminalis (Daniel and Rainnie, 2016; LeDoux and Pine 2016; Yassa et al, 2012)


References

Daniel, S. E. & Rainnie, D. G. Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis. Neuropsychopharmacology 41, 103–125 (2016). https://pubmed.ncbi.nlm.nih.gov/26096838/

LeDoux, J. E. & Pine, D. S. Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework. Am. J. Psychiatry 173, 1083–1093 (2016). https://pubmed.ncbi.nlm.nih.gov/27609244/

LeDoux, J. E. Semantics, Surplus Meaning, and the Science of Fear. Trends Cogn. Sci. 21, 303–306 (2017). https://pubmed.ncbi.nlm.nih.gov/28318937/

Johansen, J. P., Cain, C. K., Ostroff, L. E. & LeDoux, J. E. Molecular Mechanisms of Fear Learning and Memory. Cell 147, 509–524 (2011). https://pubmed.ncbi.nlm.nih.gov/22036561/

Yassa, M. A., Hazlett, R. L., Stark, C. E. L. & Hoehn-Saric, R. Functional MRI of the amygdala and bed nucleus of the stria terminalis during conditions of uncertainty in generalized anxiety disorder. J. Psychiatr. Res. 46, 1045–1052 (2012). https://pubmed.ncbi.nlm.nih.gov/22575329/