Difference between revisions of "Lewy body disease pathology"
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| − | * Both Lewy body dementia and Parkinson's disease are characterized by alpha-synuclein in neurons that form Lewy bodies | + | * Both Lewy body dementia and Parkinson's disease are characterized by alpha-synuclein in neurons that form Lewy bodies (Salardini 2019) |
| − | ** In PD, Lewy bodies begin affecting subcortical areas (brainstem, thalamus, basal ganglia) before spreading to cortex | + | ** In PD, Lewy bodies begin affecting subcortical areas (brainstem, thalamus, basal ganglia) before spreading to cortex (Salardini 2019) |
| − | ** In LBD, Lewy bodies have earlier cortical involvement (often coexisting with AD or vascular disease) affecting posterior parts of the brain | + | ** In LBD, Lewy bodies have earlier cortical involvement (often coexisting with AD or vascular disease) affecting posterior parts of the brain (Salardini 2019) |
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== References == | == References == | ||
Salardini, A. An Overview of Primary Dementias as Clinicopathological Entities. Semin. Neurol. 39, 153–166 (2019). https://pubmed.ncbi.nlm.nih.gov/30925609/ | Salardini, A. An Overview of Primary Dementias as Clinicopathological Entities. Semin. Neurol. 39, 153–166 (2019). https://pubmed.ncbi.nlm.nih.gov/30925609/ | ||
Latest revision as of 09:06, 13 June 2021
- Both Lewy body dementia and Parkinson's disease are characterized by alpha-synuclein in neurons that form Lewy bodies (Salardini 2019)
- In PD, Lewy bodies begin affecting subcortical areas (brainstem, thalamus, basal ganglia) before spreading to cortex (Salardini 2019)
- In LBD, Lewy bodies have earlier cortical involvement (often coexisting with AD or vascular disease) affecting posterior parts of the brain (Salardini 2019)
References
Salardini, A. An Overview of Primary Dementias as Clinicopathological Entities. Semin. Neurol. 39, 153–166 (2019). https://pubmed.ncbi.nlm.nih.gov/30925609/
