Lewy body disease pathology

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  • Both Lewy body dementia and Parkinson's disease are characterized by alpha-synuclein in neurons that form Lewy bodies 40
    • In PD, Lewy bodies begin affecting subcortical areas (brainstem, thalamus, basal ganglia) before spreading to cortex 40
    • In LBD, Lewy bodies have earlier cortical involvement (often coexisting with AD or vascular disease) affecting posterior parts of the brain 40

References

Salardini, A. An Overview of Primary Dementias as Clinicopathological Entities. Semin. Neurol. 39, 153–166 (2019). https://pubmed.ncbi.nlm.nih.gov/30925609/

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