22q11.2 deletion syndrome

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- most common chromosomal microdeletion in humans (1 in every 6,000 people) (O'Rourke and Murphy, 2019)

- psychiatric comorbidities affect up to ¾ of all diagnosed individuals and they have a 30x higher risk of developing psychosis and a 6x higher risk of developing schizophrenia compared to the general population (O'Rourke and Murphy, 2019)


References

O’Rourke, L. & Murphy, K. C. Recent developments in understanding the relationship between 22q11.2 deletion syndrome and psychosis. Curr. Opin. Psychiatry 32, 67–72 (2019). https://pubmed.ncbi.nlm.nih.gov/30394904/

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