Seizure incidence in psychopharmacology

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Seizure incidence per analysis of phase II and III clinical trials (between 1985 and 2004) (Alper et al, 2007)

  • Antipsychotics: clozapine, olanzapine, and quetiapine were associated with increased seizure incidence
  • OCD treatment: clomipramine was associated with increased seizure incidence (TCAs in general should be avoided in epilepsy)
  • Anxiolytics: alprazolam was associated with increased seizure incidence (other benzodiazepines were not investigated)
  • Antidepressants: bupropion IR (but not SR or XL) form was associated with increase seizure incidence
    • In other antidepressants (SSRIs, SNRIs, mirtazapine): incidence of seizures were lower compared to placebo, likely due to treatment of depression which itself lowers seizure threshold


References

Alper, K., Schwartz, K. A., Kolts, R. L. & Khan, A. Seizure Incidence in Psychopharmacological Clinical Trials: An Analysis of Food and Drug Administration (FDA) Summary Basis of Approval Reports. 10. https://pubmed.ncbi.nlm.nih.gov/17223086/

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