Executive variant or frontal AD

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  • Executive dysfunction and behavioral symptoms (Salardini 2019)
  • Shares overlaps with behavioral variant frontotemporal dementia, though frontal AD can be distinguished by: (Ljubenkov and Miller 2016)
    • greater burden of parietal and mesial temporal atrophy
    • greater degree of memory disturbance and executive dysfunction earlier in their course
    • less severe behavioral disturbances
    • FDG-PET may help distinguish areas of hypometabolism
    • amygdaloid biomarkers provide most definitive diagnostic clarity


References

Salardini, A. An Overview of Primary Dementias as Clinicopathological Entities. Semin. Neurol. 39, 153–166 (2019). https://pubmed.ncbi.nlm.nih.gov/30925609/

Ljubenkov, P. A. & Miller, B. L. A Clinical Guide to Frontotemporal Dementias. FOCUS 14, 448–464 (2016). https://pubmed.ncbi.nlm.nih.gov/31975825/

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