Huntington's disease

Diagnosis

Clinical criteria for Huntington’s disease (Folstein 1986)

1) Definite Huntington’s disease

a. Chorea, not present at birth that is insidious and progressive

b. Family history of at least one other member with typical symptoms of Huntington’s disease

2) Probable Huntington’s disease

a. Typical symptoms

b. Unobtainable family history

3) Unknown

a. Typical symptoms in the absence of family history despite proper genealogic investigation

References

Folstein, S. E., Leigh, R. J., Parhad, I. M. & Folstein, M. F. The diagnosis of Huntington’s disease. Neurology. 1986 Oct;36(10):1279-83. https://pubmed.ncbi.nlm.nih.gov/2945124/