Default Mode Network

  • Three main subdivisions: ventromedial prefrontal, dorsomedial prefrontal, and posterior cingulate (Raichle 2015)
  • Involved in self-referential thoughts (reflecting on one’s past, envisioning the future, emotion recognition) (Raichle 2015; Buckner and DiNicola, 2019)
  • Can be divided into anterior component (more involved in self-reflection / emotion) and posterior component (more involved in episodic memory / perceptual processing) (Coutinho et al, 2016).
    • Depressive / anxiety symptom scores have greater correlation with anterior components and negative correlation to posterior components (Coutinho et al, 2016; Mulders et al, 2015)


References

Buckner, R. L. & DiNicola, L. M. The brain’s default network: updated anatomy, physiology and evolving insights. Nat. Rev. Neurosci. 20, 593–608 (2019). https://pubmed.ncbi.nlm.nih.gov/31492945/

Coutinho, J. F. et al. Default mode network dissociation in depressive and anxiety states. Brain Imaging Behav. 10, 147–157 (2016). https://pubmed.ncbi.nlm.nih.gov/25804311/

Mulders, P. C., van Eijndhoven, P. F., Schene, A. H., Beckmann, C. F. & Tendolkar, I. Resting-state functional connectivity in major depressive disorder: A review. Neurosci. Biobehav. Rev. 56, 330–344 (2015). https://pubmed.ncbi.nlm.nih.gov/26234819/

Raichle, M. E. The Brain’s Default Mode Network. Annu. Rev. Neurosci. 38, 433–447 (2015). https://pubmed.ncbi.nlm.nih.gov/25938726/

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